{"id":2728,"date":"2024-04-18T02:47:32","date_gmt":"2024-04-17T18:47:32","guid":{"rendered":"https:\/\/applelatest.com\/uncategorized\/2728.html"},"modified":"2024-04-18T02:47:32","modified_gmt":"2024-04-17T18:47:32","slug":"%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e6%95%b8%e6%93%9a%e4%bb%a4%e4%ba%ba%e5%a4%b1%e6%9c%9b%ef%bc%8c%e5%b0%88%e6%b3%a8%e6%96%bc%e7%a5%9e%e7%b6%93%e9%80%80%e8%a1%8c%e6%80%a7%e7%96%be%e7%97%85%e7%9a%84-s","status":"publish","type":"post","link":"https:\/\/applelatest.com\/en\/stocks\/2728.html","title":{"rendered":"Shares of Sage Therapeutics, which specializes in neurodegenerative diseases, fall after disappointing Parkinson's data"},"content":{"rendered":"<div contentscore=\"1960\">\n<figure>\n<div>\n<div>\n<div><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-2731\" src=\"https:\/\/applelatest.com\/wp-content\/uploads\/2024\/04\/80edd6624b971a43cf13e51068112dca.jpg\" width=\"960\" height=\"540\" alt=\"80edd6624b971a43cf13e51068112dca\" title=\"80edd6624b971a43cf13e51068112dca\" srcset=\"https:\/\/applelatest.com\/wp-content\/uploads\/2024\/04\/80edd6624b971a43cf13e51068112dca.jpg 960w, https:\/\/applelatest.com\/wp-content\/uploads\/2024\/04\/80edd6624b971a43cf13e51068112dca-300x169.jpg 300w, https:\/\/applelatest.com\/wp-content\/uploads\/2024\/04\/80edd6624b971a43cf13e51068112dca-768x432.jpg 768w, https:\/\/applelatest.com\/wp-content\/uploads\/2024\/04\/80edd6624b971a43cf13e51068112dca-18x10.jpg 18w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/><\/div>\n<\/div>\n<\/div>\n<div><figcaption>Shares of Sage Therapeutics, which specializes in neurodegenerative diseases, fall after disappointing Parkinson's data<\/figcaption><\/div>\n<\/figure>\n<p>Wednesday.<strong>Sage Therapeutics, Inc.<\/strong>(NASDAQ Resonance: SAGE) announced preliminary results from the PRECEDENT Phase 2 study of dalzanemdor (SAGE-718) for the treatment of patients with mild cognitive impairment in Parkinson's disease.<\/p>\n<p>The PRECEDENT study did not reach its primary endpoint of a statistically significant difference from baseline on the Wechsler Adult Intelligence Scale, Fourth Edition-IV (WAIS-IV) coded test scores for patients treated with once-daily dalzanemdor versus those treated with placebo at Day 42.<\/p>\n<div>\n<div data-wf-benji-page-context='{\"pageUrl\":\"https:\/\/finance.yahoo.com\/news\/neurodegenerative-disorder-focused-sage-therapeutics-184152752.html\",\"spaceid\":\"1183300100\",\"site\":\"finance\",\"hashtag\":\"health\",\"lmsid\":\"a0Vd0000003tp8ZEAQ\",\"lpstaid\":\"caad58c4-e88f-317e-b86e-26cd42c9e1dc\",\"pct\":\"story\"}' data-wf-benji-wafer-config='{\"updateI13n\":true}' data-wf-benji-config='{\"positions\":{\"INARTICLE-caad58c4-e88f-317e-b86e-26cd42c9e1dc1713379637099\":{\"id\":\"INARTICLE-caad58c4-e88f-317e-b86e-26cd42c9e1dc1713379637099\",\"path\":\"\/22888152279\/us\/yfin\/ros\/dt\/us_yfin_ros_dt_mid_center\",\"region\":\"index\",\"size\":[[970,350],[728,90],[970,250],\"fluid\"],\"kvs\":{\"loc\":\"mid_center\"},\"refresh\":{\"reserved\":{\"duration\":1e+23}}}}}' id=\"sda-INARTICLE-caad58c4-e88f-317e-b86e-26cd42c9e1dc1713379637099\" data-wf-trigger=\"onLoad\" data-wf-margin=\"100 0\" data-hide-ad-string>\n<div id=\"INARTICLE-caad58c4-e88f-317e-b86e-26cd42c9e1dc1713379637099\"><\/div>\n<\/div>\n<\/div>\n<p>The WAIS-IV is the most advanced measure of adult cognitive ability.<\/p>\n<p>The total tolerability of Dalzanemdor (SAGE-718) was good and no new safety signals were identified.<\/p>\n<p>Treatment-emergent adverse events (TEAEs) occurred in 48 participants. The vast majority of TEAEs were mild to moderate in severity.<\/p>\n<p>\"We are disappointed with the results of the PRECEDENT Phase 2 study given the tremendous burden that mild cognitive impairment places on Parkinson's patients and their families,\" said Barry Greene, Chief Executive Officer of Sage Therapeutics, Inc.<\/p>\n<p>At other exploratory endpoints (e.g., the SCOPA-Cog, an indicator of cognitive functioning) the analysis showed no significant differences compared to placebo.<\/p>\n<p>Based on these data, the Company does not intend to further develop dalzanemdor (SAGE-718) in the Parkinson's disease space.<\/p>\n<p>The Company expects the dalzanemdor (SAGE-718) Phase 2 clinical development project to reach the following milestones in 2024:<\/p>\n<ul>\n<li contentscore=\"96\">\n<p>First-line data from the mid-2024 Huntington Cognitive Disorder SURVEYOR study.<\/p>\n<\/li>\n<li contentscore=\"131\">\n<p>First-line data from the LIGHTWAVE study in patients with mild cognitive impairment and mild dementia in Alzheimer's disease, late 2024.<\/p>\n<\/li>\n<li contentscore=\"110\">\n<p>First-line data from the DIMENSION study of patients with cognitive dysfunction in Huntington's disease, late 2024.<\/p>\n<\/li>\n<\/ul>\n<p><strong>Price Trend:<\/strong>Shares of SAGE stock traded down 23.80% on Wednesday, hitting $11.91.<\/p>\n<p>\"The Secret Weapon of Active Investors\" - Power up your stock market game with the #1 \"News and Everything Else\" trading tool: Benzinga Pro - Click here to start a 14-day trial!<\/p>\n<p>Get the latest stock analysis from Benzinga?<\/p>\n<p>This article, \"Sage Therapeutics Shares Focused on Neurodegenerative Diseases Fall on Disappointing Parkinson's Disease Data\" originally appeared on Benzinga.com.<\/p>\n<p><i>\u00a9 2024 Benzinga.com. Benzinga does not provide investment advice. Press Release: Press Release: Press Release: Press Release: Press Release: Press Release: Press Release: Press Release: Press Release: Press Release.<\/i><\/p>\n<div id=\"view-cmts-cta-caad58c4-e88f-317e-b86e-26cd42c9e1dc\"><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>On Wednesday, Sage Therapeutics (NASDAQ Resonance: SAGE) announced preliminary results from the PRECEDENT Phase 2 study of dalzanemdor (SAGE-718) for the treatment of patients with mild cognitive impairment in Parkinson's Disease.The PRECEDENT study did not reach its primary endpoint of a significant difference in coded scores on the Wechsler Adult Intelligence Scale Fourth Edition-IV (WAIS-IV) (WAIS-IV) compared to baseline on the patients who were treated with dalzanemdor once daily on Day 42, as compared to patients who were treated with placebo. There was a statistically significant difference from baseline between patients treated with dalzanemdor and those treated with placebo on the coded test scores of the Wechsler Adult Intelligence Scale, Fourth Edition-IV (WAIS-IV), a measure that is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[55],"tags":[2098,2102,1917,2095,2101,2099,2100,2096,2103,2097],"blocksy_meta":"","yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v19.6 (Yoast SEO v19.12) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u5e15\u91d1\u68ee\u75c5\u6578\u64da\u4ee4\u4eba\u5931\u671b\uff0c\u5c08\u6ce8\u65bc\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u7684 Sage Therapeutics \u80a1\u50f9\u4e0b\u8dcc - Apple Latest<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/applelatest.com\/en\/stocks\/2728.html\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5e15\u91d1\u68ee\u75c5\u6578\u64da\u4ee4\u4eba\u5931\u671b\uff0c\u5c08\u6ce8\u65bc\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u7684 Sage Therapeutics \u80a1\u50f9\u4e0b\u8dcc\" \/>\n<meta property=\"og:description\" content=\"\u672c\u5468\u4e09\uff0cSage Therapeutics\u516c\u53f8\uff08\u7d0d\u65af\u9054\u5c05\u80a1\u7968\u4ee3\u78bc\uff1aSAGE\uff09\u516c\u4f48\u4e86dalzanemdor\uff08SAGE-718\uff09\u6cbb\u7642\u5e15\u91d1\u68ee\u75c5\u8f15\u5ea6\u8a8d\u77e5\u969c\u7919\u60a3\u8005\u7684PRECEDENT 2\u671f\u7814\u7a76\u7684\u521d\u6b65\u7d50\u679c\u3002PRECEDENT\u7814\u7a76\u672a\u9054\u5230\u5176\u4e3b\u8981\u7d42\u9ede\uff0c\u5373\u5728\u7b2c42\u5929\u6642\uff0c\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21dalzanemdor\u6cbb\u7642\u7684\u60a3\u8005\u8207\u63a5\u53d7\u5b89\u6170\u5291\u6cbb\u7642\u7684\u60a3\u8005\u5728\u97cb\u6c0f\u6210\u4eba\u667a\u80fd\u91cf\u8868\u7b2c\u56db\u7248-IV\uff08WAIS-IV\uff09\u7de8\u78bc\u6e2c\u8a66\u5f97\u5206\u4e0a\u8207\u57fa\u7dda\u76f8\u6bd4\u6709\u986f\u8457\u7d71\u8a08\u5b78\u5dee\u7570\u3002WAIS-IV\u662f\" \/>\n<meta property=\"og:url\" content=\"https:\/\/applelatest.com\/en\/stocks\/2728.html\/\" \/>\n<meta property=\"og:site_name\" content=\"Apple Latest\" \/>\n<meta property=\"article:published_time\" content=\"2024-04-17T18:47:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/s.yimg.com\/ny\/api\/res\/1.2\/ftcaV3Vs8TolbpHooU38AA--\/YXBwaWQ9aGlnaGxhbmRlcjt3PTk2MDtoPTU0MA--\/https:\/\/media.zenfs.com\/en\/Benzinga\/80edd6624b971a43cf13e51068112dca\" \/>\n<meta name=\"author\" content=\"applelatest\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"applelatest\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/applelatest.com\/uncategorized\/2728.html#article\",\"isPartOf\":{\"@id\":\"https:\/\/applelatest.com\/uncategorized\/2728.html\"},\"author\":{\"name\":\"applelatest\",\"@id\":\"https:\/\/applelatest.com\/#\/schema\/person\/ed60be871043e449bf7d8e44ac3499a7\"},\"headline\":\"\u5e15\u91d1\u68ee\u75c5\u6578\u64da\u4ee4\u4eba\u5931\u671b\uff0c\u5c08\u6ce8\u65bc\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u7684 Sage Therapeutics \u80a1\u50f9\u4e0b\u8dcc\",\"datePublished\":\"2024-04-17T18:47:32+00:00\",\"dateModified\":\"2024-04-17T18:47:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/applelatest.com\/uncategorized\/2728.html\"},\"wordCount\":43,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/applelatest.com\/#organization\"},\"keywords\":[\"PRECEDENT\u7814\u7a76\",\"WAIS-IV\",\"\u521d\u6b65\u7d50\u679c\",\"\u5e15\u91d1\u68ee\u75c5\",\"\u8a8d\u77e5\u529f\u80fd\",\"\u8a8d\u77e5\u80fd\u529b\",\"\u8a8d\u77e5\u969c\u7919\",\"\u8cfd\u5091\u6cbb\u7642\u516c\u53f8\",\"\u8cfd\u5091\u6cbb\u7642\u516c\u53f8\u80a1\u7968\",\"\u8f15\u5ea6\u8a8d\u77e5\u969c\u7919\"],\"articleSection\":[\"stocks\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/applelatest.com\/uncategorized\/2728.html#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/applelatest.com\/uncategorized\/2728.html\",\"url\":\"https:\/\/applelatest.com\/uncategorized\/2728.html\",\"name\":\"\u5e15\u91d1\u68ee\u75c5\u6578\u64da\u4ee4\u4eba\u5931\u671b\uff0c\u5c08\u6ce8\u65bc\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u7684 Sage Therapeutics \u80a1\u50f9\u4e0b\u8dcc - 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